Endocrine Abstracts

The water channel aquaporin-2 (AQP2) of the kidney connecting tubule and collecting ducts, plays an essential role in maintaining body water balance. AQP2 is regulated by the peptide hormone arginine vasopressin (AVP), which exerts parts of its effects through the type 2 vasopressin receptor (AVPR2), expressed throughout the distal nephron. Disrupted function or regulation of AQP2 or the AVPR2 results in nephrogenic diabetes insipidus (NDI). NDI is a common clinical condition ...